The major landuse is pastoral but includes several national parks and regional reserves, and some marginal cropping in the far south around the towns of Peterborough and Orroroo. The northern town of Marree on the original Ghan railway line is the jumping off point for the famous Birdsville Track.

The population is small and, apart from the far southern fringe, very sparse. The Lake Eyre Basin Coordinating Group is working to establish linkages with existing representative bodies in the Lake Frome Region to ensure stakeholders of the area have a voice in the wider Lake Eyre Basin process.

The Eastern and Northern Flinders Ranges along with the Olary Ranges fall within the Lake Frome catchment. The bioregions represented in this region are the Stony Plains, Flinders and Olary Ranges, Broken Hill Complex, Simpson/Strzelecki Dunefields and the Channel Country.

The Lake Frome Region contributes very little water to Lake Eyre itself but is an integral part of the overall Lake Eyre drainage basin.